• Adherence to antihypertensive medication in Russia: A scoping review of studies on levels, determinants and intervention strategies published between 2000 and 2017 

      Bochkareva, Elena Viktorovna; Butina, Ekaterina Kronidovna; Kim, Irina Vitalievna; Kontsevaya, Anna Vasilievna; Drapkina, Oxana Mikhailovna; Leon, David Adrew; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-25)
      <p><i>Background - </i>Arterial hypertension (HT) is common in the Russian adult population, with half of affected individuals inadequately controlled. Low adherence to medication seems likely to be a factor. We report a scoping review of studies on adherence to antihypertensive therapy (AHT) in Russia to determine the extent of research undertaken, the frequency of adherence among adults diagnosed ...
    • The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis 

      Imahori, Yume; Mathiesen, Ellisiv B.; Morgan, Katy E.; Frost, Chris; Hughes, Alun D.; Hopstock, Laila Arnesdatter; Johnsen, Stein Harald; Emaus, Nina; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-17)
      <i>Background</i> - Few reports are available on the contribution of general and abdominal obesity to the progression of carotid atherosclerosis in late adulthood. This study investigated the impact of four simple anthropometric measures of general and abdominal obesity on the progression of carotid atherosclerosis and the extent to which the association between adiposity and the progression of ...
    • Availability and Affordability of Medicines for the Treatment of Cardiovascular Diseases in Pharmacies in Six Regions of the Russian Federation 

      Imaeva, Asiia E; Balanova, Yulia A; Kontsevaya, Anna V; Kapustina, Anna V; Duplyakov, Dmitry V.; Malysheva, Olga H; Osipova, Irina V.; Petrichko, Tatiana A; Kropanin, Georgiy I; Kasimov, Riza A; Leon, David Adrew; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <i>Aim</i>: To evaluate the availability and affordability of medicines used to treat of cardiovascular diseases (CVD) in several regions of the Russian Federation with different climatic, geographic, economic and demographic characteristics.<p> <p><i>Material and methods</i>: The study was conducted in 6 regional capitals, chosen to differ in geographically, economically, and demographically. ...
    • The changing relation between alcohol and life expectancy in Russia in 1965-2017 

      Danilova, Inna; Shkolnikov, Vladimir M.; Evgenij, Andreev; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-18)
      Introduction and Aims. In the 1990s, a strong inverse relationship between life expectancy (LE) in Russia and mortality from alcohol poisoning was observed. This association is remarkable as this cause accounts for less than 2% of deaths each year. It can be explained by treating the alcohol poisoning mortality as the best available measure in Russia of the population prevalence of harmful drinking ...
    • Disparities in length of life across developed countries: Measuring and decomposing changes over time within and between country groups 

      Timonin, Sergey; Shkolnikov, Vladimir M.; Jasilionis, Domantas; Grigoriev, Pavel; Jdanov, Dmitri A.; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-11)
      Background. Over the past half century the global tendency for improvements in longevity has been uneven across countries. This has resulted in widening of inter-country disparities in life expectancy. Moreover, the pattern of divergence appears to be driven in part by processes at the level of country groupings defined in geopolitical terms. A systematic quantitative analysis of this phenomenon has ...
    • Effect of adiposity on differences in carotid plaque burden in studies conducted in Norway and Russia: a cross-sectional analysis of two populations at very different risk of cardiovascular mortality 

      Imahori, Yume; Frost, Chris; Mathiesen, Ellisiv B.; Ryabikov, Andrey; Kudryavtsev, Alexander V; Malyutina, Sofia; Kornev, Michael; Hughes, Alun D; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      <i>Objectives</i> - Large differences exist in the burden of cardiovascular disease (CVD) between Russia and Western European countries including Norway. Obesity prevalence may contribute to the differences. We investigated whether difference in the level of adiposity, assessed using body mass index and waist-to-hip ratio(WHR), could explain intercountry differences in the burden of carotid plaque, ...
    • Evidence for a direct harmful effect of alcohol on myocardial health: A large cross-sectional study of consumption patterns and cardiovascular disease risk biomarkers from northwest Russia, 2015 to 2017 

      Iakunchykova, Olena; Averina, Maria; Kudryavtsev, Alexander V; Wilsgaard, Tom; Soloviev, Andrey; Schirmer, Henrik; Cook, Sarah Anne; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      <i>Background</i> - Alcohol drinking is an increasingly recognized risk factor for cardiovascular disease. However, there are few studies of the impact of harmful and hazardous drinking on biomarkers of myocardial health. We conducted a study in Russia to investigate the impact of heavy drinking on biomarkers of cardiac damage and inflammation.<p><p> <i>Methods and Results</i> - The Know Your ...
    • Hospital admissions and mortality in the 15 years after a first-time hospital contact with an alcohol problem: A prospective cohort study using the entire Danish population 

      Askgaard, Gro; Leon, David Adrew; Deleuran, Thomas; Tolstrup, Janne S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
      <b><p>Background</b> Potential benefits of preventing continued alcohol intake in individuals presenting at the hospital with an alcohol problem can be highlighted by studying their excess risk of subsequent morbidity and mortality. <b><p>Methods</b> All Danish residents with a first-time hospital contact with alcohol problems (intoxication, harmful use or dependence) in 1998–2002 were followed ...
    • Hospital stage of myocardial infarction treatment in 13 regions of Russian Federation by results of the international research 

      Kontsevaya, Anna V.; Bates, Katie; Goryachkin, Evgeny A.; Bobrova, Natalia; Syromiatnikova, Liudmila I.; Popova, Yulia V.; Platonov, Dmitry Yu.; Osipova, Irina V.; Nedbaikin, Andrei M.; Malorodova, Tatyana N.; Mirolyubova, Olga A.; Kryuchkov, Dmitry V.; Khaisheva, Larisa A.; Galyavich, Albert S.; Franz, Maria V.; Efanov, Alexey Yu.; Duplyakov, Dmitry V.; Drapkina, Oxana M.; Leon, David Adrew; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018)
      <i>Aim</i>: To describe the characteristics of the patient with MI who is admitted to a hospital and to characterize the main diagnostic and treatment interventions in clinic.<p> <p><i>Material and methods</i>: This study is observational and the part of big international project. It includes a representative sample of patients with MI admitted to 16 clinics in 13 regions of Russian Federation ...
    • Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18 

      Cook, Sarah; Malyutina, S; Kudryavtsev, Alexander; Averina, Maria; Bobrova, Natalia; Boytsov, S; Brage, S; Clark, TG; Diez Benavente, S; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Hughes, A; Johansen, Heidi; Kholmatova, Kamila; Kichigina, A; Kontsevaya, Anna; Kornev, M; Leong, D; Magnus, Per; Mathiesen, Ellisiv B.; McKee, M; Morgan, K; Nilssen, Odd-Ragnar; Plakhov, I; Quint, JK; Rapala, A; Ryabikov, A; Saburova, Lyudmila; Schirmer, Henrik; Shapkina, M; Shiekh, Suhail; Shkolnikov, VM; Stylidis, Michael; Voevoda, Mikhail; Westgate, Kate; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
      Russia has one of the highest rates of cardiovascular disease in the world. The International Project on Cardiovascular Disease in Russia (IPCDR) was set up to understand the reasons for this. A substantial component of this study was the Know Your Heart Study devoted to characterising the nature and causes of cardiovascular disease in Russia by conducting large cross-sectional surveys in two Russian ...
    • Low maternal capital predicts life history trade-offs in daughters: Why adverse outcomes cluster in individuals 

      Wells, Jonathan C.K.; Cole, Tim J.; Cortina-Borja, Mario; Sear, Rebecca; Leon, David Adrew; Marphatia, Akanksha A.; Murray, Joseph; Wehrmeister, Fernando César; Oliveira, Paula D.; Goncalves, Helen; Oliveira, Isabel O.; Menezes, Ana Maria B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-31)
      <i>Background</i>: Some individuals appear prone to multiple adverse outcomes, including poor health, school dropout, risky behavior and early reproduction. This clustering remains poorly understood. Drawing on evolutionary life history theory, we hypothesized that maternal investment in early life would predict the developmental trajectory and adult phenotype of female offspring. Specifically, we ...
    • The management of acute myocardial infarction in the Russian Federation: Protocol for a study of patient pathways [version 2; referees: 2 approved] 

      Kontsevaya, Anna V; Bobrova, Natalia; Barbarash, Olga; Duplyakov, Dmitry; Efanov, Alexey; Galyavich, Albert; Frants, Maria; Khaisheva, Larisa; Malorodova, Tatyana; Mirolyubova, Olga; Nedbaikin, Andrei; Osipova, Irina; Platonov, Dmitry; Posnenkova, OIga; Syromiatnikova, Liudmila; Bates, Katie; Leon, David Adrew; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)
      <i>Background</i>: Death rates from cardiovascular disease in Russia are among the highest in the world. In recent years, the Russian government has invested substantially in the healthcare system, with a particular focus on improving access to advanced technology, especially for acute myocardial infarction (AMI). This protocol describes a study to understand the management of AMI in different Russian ...
    • Patterns in the relationship between life expectancy and gross domestic product in Russia in 2005-15: a cross-sectional analysis 

      Shkolnikov, Vladimir M.; Andreev, Evgeny M; Tursun-zade, Rustam; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-04)
      <i>Background</i> - Since 2005, Russia has made substantial progress, experiencing an almost doubling of per-capita gross domestic product by purchasing power parity (GDP [PPP]) to US$24 800 and witnessing a 6-year increase in life expectancy, reaching 71·4 years by 2015. Even greater gains in GDP (PPP) were seen for Moscow, the Russian capital, reaching $43 000 in 2015 and with a life expectancy ...
    • Pharmacological treatment of hypertension and hyperlipidemia in Izhevsk, Russia 

      Cybulsky, Marta; Cook, Sarah; Kontsevaya, Anna V; Vasiljev, Maxim; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-03)
      Background: Cardiovascular disease (CVD) is the leading cause of death in Russia. Hypertension and hyperlipidemia are important risk factors for CVD that are modifiable by pharmacological treatment and life-style changes. We aimed to characterize the extent of the problem in a typical Russian city by examining the prevalence, treatment and control rates of hypertension and hyperlipidemia and ...
    • Physical assault in the previous year and total and cause-specific mortality in Russia: A case-control study of men aged 25-54 years 

      Bhavsar, Vishal; Cook, Sarah; Saburova, Lyudmila; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-19)
      Background: Violence has important health effects. The results of exposure to physical violence include, but may not be limited to, death from suicide and homicide. The connection between the experience of assault and risk of death from causes other than homicide and suicide has rarely been examined.<p> <p>Methods: We analysed data from the first Izhevsk Family Study (IFS-1), a populationbased ...
    • Primary care use and cardiovascular disease risk in Russian 40–69 year olds: a cross-sectional study 

      Petersen, Jakob; Kontsevaya, Anna V.; McKee, Martin; Richardson, E.; Cook, Sarah Anne; Malyutina, Sofia; Kudryavtsev, Alexander V; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-04)
      <i>Background</i> - The Russian Federation has very high cardiovascular disease (CVD) mortality rates compared with countries of similar economic development. This cross-sectional study compares the characteristics of CVD-free participants with and without recent primary care contact to ascertain their CVD risk and health status.<br><br> <i>Methods</i> - A total of 2774 participants aged 40–69 ...
    • Reducing geographic inequalities in access times for acute treatment of myocardial infarction in a large country: the example of Russia 

      Timonin, Sergey; Kontsevaya, Anna; McKee, Martin; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-01)
      Background: Russia has the largest area of any country in the world and has one of the highest cardiovascular mortality rates. Over the past decade, the number of facilities able to perform percutaneous coronary interventions (PCIs) has increased substantially. We quantify the extent to which the constraints of geography make equitable access to this effective technology difficult to ...
    • Reflection on modern methods: Calculating a sample size for a repeatability sub-study to correct for measurement error in a single continuous exposure 

      Morgan, Katy E; Cook, Sarah; Leon, David Adrew; Frost, Chris (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-23)
      Using a continuous exposure variable that is measured with random error in a univariable linear regression model leads to regression dilution bias: the observed association between the exposure and outcome is smaller than it would be if the true value of the exposure could be used. A repeatability sub-study, where a sample of study participants have their data measured again, can be used to correct ...
    • Seroprevalence of SARS-Cov-2 Antibodies in Adults, Arkhangelsk, Russia 

      Krieger, Ekaterina Anatoljevna; Kudryavtsev, Alexander V; Sharashova, Ekaterina; Postoev, Vitaly; Belova, Natalia; Shagrov, Leonid; Zvedina, Julia; Drapkina, Oxana; Kontsevaya, Anna; Shalnova, Svetlana; Brenn, Tormod; Shkolnikov, Vladimir M.; Eggo, Rosalind M.; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02)
      Population-based data on coronavirus disease in Russia and on the immunogenicity of the Sputnik V vaccine are sparse. In a survey of 1,080 residents of Arkhangelsk 40–75 years of age, 65% were seropositive for IgG. Fifteen percent of participants had been vaccinated; of those, 97% were seropositive.
    • Socio-demographic, behavioural and psycho-social factors associated with depression in two Russian cities 

      Cook, Sarah; Saburova, Lyudmila; Bobrova, Natalia; Avdeeva, Ekaterina; Malyutina, Sofia; Kudryavtsev, Alexander V; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-04)
      Background - Russia has a high burden of suicide and alcohol-attributable mortality. However there have been few studies of the epidemiology of depression.<p> <p>Methods - The study population was 5077 men and women aged 35-69 years from a cross-sectional population based survey in the cities of Arkhangelsk and Novosibirsk (2015-17). Moderate depression was defined as Patient Health Questionnaire-9 ...